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A dietary approach has proven to be effective in alleviating symptoms of premenstrual syndrome. In our previous studies, magnesium improved premenstrual irritability and mood scoings. In this double-blind, placebo-controlled study, we evaluated the effects of a new dietetic preparation (Sillix Donna, Giuliani) in 40 patients affected by mild to moderate premenstrual syndrome. Premenstrual symptoms were scored in both follicular and luteal phases, at baseline, at 2nd, 4th and 6th month of treatment by using the Menstrual Distress Questionnaire (MDQ). Twenty patients were randomised to receive the active preparation and 20 placebo. MDQ scores at baseline were similar in the two groups. Five patients of the placebo group dropped out because of treatment failure. No side effects were observed. Both treatments reduced symptoms already in the 2nd month, but the active preparation was more effective at all time controls (p < 0.05); at the 6th month it significantly reduced premenstrual MDQ scores to 18% of baseline values, placebo only to 73%. These data demonstrate that Sillix Donna is effective in reducing premenstrual distress.
F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
November 1995,
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F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
September 1992,
Obstetrics and gynecology,
F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
September 1979,
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F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
April 2023,
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F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
January 1985,
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F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
January 1987,
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F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
January 2021,
Evidence-based complementary and alternative medicine : eCAM,
F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
January 2018,
Journal of evidence-based integrative medicine,
F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
June 1993,
Archives of general psychiatry,
F Facchinetti, and
R E Nappi, and
M G Sances, and
I Neri, and
G Grandinetti, and
A Genazzani
May 2003,
Pharmacotherapy,
