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Serum 25-hydroxyvitamin D3 levels were determined in chronic hepatic diseases by a radioreceptor assay and correlated with serum albumin, calcium and anorganic phosphate, 25-hydroxyvitamin D3 serum levels were significantly lower inall chronic hepatic diseses compared to normals. The low levels are correlated with the degree of parenchymal damage, not with the etiology of hepatic disease. In alcoholic liver disease thus 25=hydroxyvitamin D3 levels are significantly lower when cirrhosis is present than in mere fatty liver. Anorganic phosphate and calcium were close to the lower range of normal and significantly lower than in the control group studied.
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