Biomaterial Database

Increase of transforming growth factor-beta 1 in gingival crevicular fluid during human orthodontic tooth movement. 1996

S Uematsu, and M Mogi, and T Deguchi

Department of Orthodontics, Matsumoto Dental College, Nagano, Japan.

The purpose of this study was to identify and quantify transforming growth factor-beta 1 (TGF-beta 1) in human gingival crevicular fluid, and to investigate changes during orthodontic tooth movement. Twelve patients (mean age, 14.4 yr) participated. An upper canine of each patient having one treatment for distal movement served as the experimental tooth; the contralateral and antagonistic canines were used as controls. The gingival crevicular fluid around the experimental and two control teeth was taken from each participant immediately before activation, and at 1, 24 and 168 h after the initiation of tooth movement. TGF-beta 1 was determined by enzyme-linked immunosorbent assay. The concentration of TGF-beta 1 was significantly higher in the experimental group than in the controls at 24 h after the experiment had begun, whereas TGF-beta 1 remained at baseline throughout the experiment for the two control groups. The presence of TGF-beta 1 in the gingival crevicular fluid was also identified by Western blot analysis. These results suggest that TGF-beta 1 is associated with the bone remodelling that occurs during orthodontic tooth movement.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D003481	Cuspid	The third tooth to the left and to the right of the midline of either jaw, situated between the second INCISOR and the premolar teeth (BICUSPID). (Jablonski, Dictionary of Dentistry, 1992, p817)	Canine Tooth,Canine Teeth,Cuspids,Teeth, Canine,Tooth, Canine
D004797	Enzyme-Linked Immunosorbent Assay	An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.	ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D005883	Gingival Crevicular Fluid	A fluid occurring in minute amounts in the gingival crevice, believed by some authorities to be an inflammatory exudate and by others to cleanse material from the crevice, containing sticky plasma proteins which improve adhesions of the epithelial attachment, have antimicrobial properties, and exert antibody activity. (From Jablonski, Illustrated Dictionary of Dentistry, 1982)	Gingival Exudate,Crevicular Fluid, Gingival,Crevicular Fluids, Gingival,Exudate, Gingival,Exudates, Gingival,Fluid, Gingival Crevicular,Fluids, Gingival Crevicular,Gingival Crevicular Fluids,Gingival Exudates
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000539	Alveolar Process	The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.	Alveolar Ridge,Alveolar Processes,Process, Alveolar,Processes, Alveolar,Ridge, Alveolar
D014087	Tooth Movement Techniques	Orthodontic techniques used to correct the malposition of a tooth or teeth.	Tooth Depression,Tooth Intrusion,Tooth Movement, Minor,Tooth Uprighting,Orthodontic Tooth Movement,Depression, Tooth,Depressions, Tooth,Intrusion, Tooth,Intrusions, Tooth,Minor Tooth Movement,Minor Tooth Movements,Movement Technique, Tooth,Movement Techniques, Tooth,Movement, Orthodontic Tooth,Movements, Orthodontic Tooth,Orthodontic Tooth Movements,Technique, Tooth Movement,Techniques, Tooth Movement,Tooth Depressions,Tooth Intrusions,Tooth Movement Technique,Tooth Movement, Orthodontic,Tooth Movements, Minor,Tooth Movements, Orthodontic,Tooth Uprightings,Uprighting, Tooth,Uprightings, Tooth

Related Publications

S Uematsu, and M Mogi, and T Deguchi

Alkaline phosphatase activity in gingival crevicular fluid during human orthodontic tooth movement.

November 2002, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics,

S Uematsu, and M Mogi, and T Deguchi

Leptin Levels in Gingival Crevicular Fluid during Orthodontic Tooth Movement.

November 2021, Journal of pharmacy & bioallied sciences,

S Uematsu, and M Mogi, and T Deguchi

Leptin levels in gingival crevicular fluid during orthodontic tooth movement.

May 2010, The Angle orthodontist,

S Uematsu, and M Mogi, and T Deguchi

Prostaglandin E (PGE) and interleukin-1 beta (IL-1 beta) levels in gingival crevicular fluid during human orthodontic tooth movement.

April 1994, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics,

S Uematsu, and M Mogi, and T Deguchi

Characterization of proteoglycan metabolites in human gingival crevicular fluid during orthodontic tooth movement.

May 1994, Archives of oral biology,

S Uematsu, and M Mogi, and T Deguchi

Glycosaminoglycans in human gingival crevicular fluid during orthodontic movement.

January 1988, Archives of oral biology,

S Uematsu, and M Mogi, and T Deguchi

The level of cathepsin B in gingival crevicular fluid during human orthodontic tooth movement.

February 2003, European journal of orthodontics,

S Uematsu, and M Mogi, and T Deguchi

Secretory microRNA-29 expression in gingival crevicular fluid during orthodontic tooth movement.

January 2018, PloS one,