Biomaterial Database

Immunohistochemical evaluation of lymph node micrometastases from gastric carcinomas. 1997

K Ishida, and T Katsuyama, and A Sugiyama, and S Kawasaki

First Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

BACKGROUND The clinicopathologic significance of micrometastases to lymph nodes, consisting of a single carcinoma cell or a small cluster of carcinoma cells and confirmed only by special staining, was evaluated in patients with gastric carcinoma. METHODS The authors studied 2446 lymph nodes removed during surgery for 109 cases of gastric carcinoma, including Stages I, II, III and IV. Tissue preparations were stained with hematoxylin and eosin (H&E), Alcian blue in combination with periodic acid-Schiff stain, and antibodies against cytokeratin and carcinoembryonic antigen (CEA). RESULTS Metastases were confirmed in 230 lymph nodes (9.4%) stained with H & E, and an additional 201 lymph nodes (17.6%) had micrometastases identified only by immunostaining for cytokeratin (197 lymph nodes) and/or CEA (66). Carcinomas with micrometastases had significantly worse prognoses at Stage II. Between the two histologic types of gastric carcinoma, the diffuse type had more micrometastases than the intestinal type. CONCLUSIONS The findings of this study indicate that the presence of micrometastases in lymph nodes is an indispensable factor in determining the prognosis of gastric carcinoma patients.

UI	MeSH Term	Description	Entries
D008198	Lymph Nodes	They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.	Lymph Node,Node, Lymph,Nodes, Lymph
D008207	Lymphatic Metastasis	Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.	Lymph Node Metastasis,Lymph Node Metastases,Lymphatic Metastases,Metastasis, Lymph Node
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009367	Neoplasm Staging	Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.	Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults