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The hypothesis was tested that 7-sulfooxymethylbenz[a]anthracene (7-SBA) is an ultimate electrophilic and carcinogenic form of 7-hydroxymethylbenz[a]anthracene. In conformity with this hypothesis, 7-SBA was more carcinogenic than 7-HBA in inducing sarcomas at the site of repeated subcutaneous injection. These metabolites were individually administered to female Sprague-Dawley rats, beginning at 30 days of age, in 0.2 mumol doses given three times each week for 20 doses. One year after the first injection of 7-SBA, seven of thirteen female Sprague-Dawley rats had developed sarcomas. 7-HBA, on the other hand, had induced sarcomas at the site of injection in only two of tweleve rats. No tumors developed either in the control group given sesame oil:DMSO only or in the untreated control group. It would appear from the results summarized here that the search for an ultimate electrophilic and carcinogenic form of 7-HBA has been successful.
J W Flesher, and
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A F Lehner
September 1982,
Applied and environmental microbiology,
J W Flesher, and
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A F Lehner
February 1986,
Carcinogenesis,
J W Flesher, and
J Horn, and
A F Lehner
September 1972,
Xenobiotica; the fate of foreign compounds in biological systems,
J W Flesher, and
J Horn, and
A F Lehner
March 1974,
International journal of cancer,
J W Flesher, and
J Horn, and
A F Lehner
January 1981,
Carcinogenesis,
J W Flesher, and
J Horn, and
A F Lehner
February 1991,
Carcinogenesis,
J W Flesher, and
J Horn, and
A F Lehner
June 1990,
Biochemical and biophysical research communications,
J W Flesher, and
J Horn, and
A F Lehner
January 1985,
Carcinogenesis; a comprehensive survey,
J W Flesher, and
J Horn, and
A F Lehner
February 2018,
Chemical science,
J W Flesher, and
J Horn, and
A F Lehner
March 1948,
Journal of the American Chemical Society,
