-transparent.png){kind=logo}
A study was made of the in vitro effects of recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft agar clonogenic assay. Stimulation of megakaryocyte numbers was seen in liquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration led to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming efficiencies was seen for the remaining 3 specimens. These results suggest that PEG-rHuMGDF will not stimulate tumour growth in vivo.
Related Publications
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
April 1996,
Blood,
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
June 1992,
International journal of hematology,
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
October 1998,
The Annals of thoracic surgery,
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
September 1998,
Toxicological sciences : an official journal of the Society of Toxicology,
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
November 1996,
Stem cells (Dayton, Ohio),
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
March 1987,
British journal of haematology,
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
January 1992,
European journal of cancer (Oxford, England : 1990),
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
October 1990,
Experimental hematology,
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
January 1998,
Journal of thrombosis and thrombolysis,
S H Lang, and
C M West, and
L Jones, and
B Brooks, and
C Kasper, and
E deWynter, and
N G Testa
January 1987,
Journal of biological regulators and homeostatic agents,
