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A possibility of step-wise induction of microsomal monooxygenases after injection of phenobarbital in the presence of 3-methylcholanthrene-caused induction was studied. It was found that the ratio of the high- and low-spin types of cytochrome, rather than the position of the CO-peak of its reduced form is a criterion for functional specificity of hemoprotein. Induction by phenobarbital appears possible under conditions when the inductor binding to microsomal hemoprotein is lacking, since cytochrome P-488 has no binding sites for phenobarbital. It is assumed that under microsomal monooxygenases induction by phenobarbital activation of genome and subsequent protein synthesis are operated by the substrate rather than by products of its primary metabolism in microsomes.
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
January 1989,
Chemico-biological interactions,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
January 1979,
Biochimica et biophysica acta,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
January 1979,
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
January 1979,
Biology bulletin of the Academy of Sciences of the USSR. Akademiia nauk SSSR,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
November 1972,
Toxicology and applied pharmacology,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
October 1990,
Biokhimiia (Moscow, Russia),
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
March 1985,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
January 1987,
Voprosy meditsinskoi khimii,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
January 1982,
Acta pharmacologica et toxicologica,
I B Tsyrlov, and
O A Gromova, and
N B Rivkind, and
G M Vakulin, and
V V Liakhovich
July 1974,
Research communications in chemical pathology and pharmacology,
