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Water and saline loading and Lasix administration lead to the intensification of the renal kallikrein-kinin system activity in rats. A positive correlation between the kallikrein excretion, urine volume and "osmotically free water" clearance was established in water and osmotic diuresis. There was the highest amount of kallikrein excreted by the kidneys during the "escape" phenomenon after saline loading. Kallikrein excretion correlated positively with sodium excretion in osmotic diuresis. The role played by the kallikrein-kinin system in control of diuresis, sodium excretion and concentrating capacity of the kidneys is discussed.
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