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As a result of experience at the Montreal General Hospital, it has been found that intravenous guanethidine blockade of extremities has therapeutic, prophylactic and diagnostic value in conditions where the aetiology is a disorder of sympathetic nervous conduction. The properties of guanethidine, namely its selective action on blocking the sympathetic nervous system peripherally, together with its long half time and rapid tissue fixation, render it a very useful drug in techniques where an isolated limb is blocked with guanethidine. Experience on a 18-month basis suggests that the procedure of intravenous guanethidine blockade offers exceptionally good results for a non-invasive technique. Work is now in progress to study the possible use of guanethidine in the treatment of phantom limb pain, and also to see whether other drugs, such as thymoxamine, could be used in a similar fashion to guanethidine.
A J Holland, and
K H Davies, and
D H Wallace
July 1979,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
A J Holland, and
K H Davies, and
D H Wallace
August 1981,
Anaesthesia,
A J Holland, and
K H Davies, and
D H Wallace
January 1989,
Annales de medecine interne,
A J Holland, and
K H Davies, and
D H Wallace
January 1982,
Acta chirurgica Scandinavica,
A J Holland, and
K H Davies, and
D H Wallace
May 1974,
Lancet (London, England),
A J Holland, and
K H Davies, and
D H Wallace
June 1974,
Lancet (London, England),
A J Holland, and
K H Davies, and
D H Wallace
April 1976,
British medical journal,
A J Holland, and
K H Davies, and
D H Wallace
August 1979,
British medical journal,
A J Holland, and
K H Davies, and
D H Wallace
June 1990,
The Clinical journal of pain,
A J Holland, and
K H Davies, and
D H Wallace
November 1996,
Acta anaesthesiologica Scandinavica,
