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In a clinical trial, 42 patients with abdominal Burkitt's lymphoma (BL) were treated with a combination regimen, code-named CVA, consisting of cyclophosphamide (CTX), vincristine, and cystosine arabinoside. In addition, intrathecal methotrexate (i.t. MTX) was administered as prophylaxis against subsequent central nervous system (CNS) involvement. Induced remissions, relapse, and survival were compared with those in a preceding group of 44 patients with abdominal BL treated with CTX along. Remission rate did not differ significantly in the two treatment groups, although induced remissions were higher in the CVA plus i.t. MTX-treated group (94% vs. 83%). Remission duration was significantly increases (p less than .05) and CNS relapse significantly reduced (p less than .05) in the group treated with CVA and i.t. MTX. The combination therapy was associated with higher early deaths during treatment, which adversely affected the overally survival. It is suggested that a reduction of the initial chemotherapeutic doses, particularly for patients with extensive tumor load, could further improve on the results of this trial.
F K Nkrumah, and
I V Perkins, and
R J Biggar
January 1993,
Neoplasma,
F K Nkrumah, and
I V Perkins, and
R J Biggar
September 1985,
Indian pediatrics,
F K Nkrumah, and
I V Perkins, and
R J Biggar
October 1986,
Gan no rinsho. Japan journal of cancer clinics,
F K Nkrumah, and
I V Perkins, and
R J Biggar
December 1972,
Cancer,
F K Nkrumah, and
I V Perkins, and
R J Biggar
June 1969,
British medical journal,
F K Nkrumah, and
I V Perkins, and
R J Biggar
October 1966,
Lancet (London, England),
F K Nkrumah, and
I V Perkins, and
R J Biggar
August 1971,
British medical journal,
F K Nkrumah, and
I V Perkins, and
R J Biggar
January 1982,
Medical and pediatric oncology,
F K Nkrumah, and
I V Perkins, and
R J Biggar
September 2010,
Annals of surgical oncology,
F K Nkrumah, and
I V Perkins, and
R J Biggar
August 1990,
Deutsche medizinische Wochenschrift (1946),
