BIOMAT Database Logo BIOMAT Database Logo

Plasma tryptophan levels and tryptophan/neutral amino acid ratios in obsessive-compulsive patients with and without depression. 1997

L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Italy. bellodl@rsisi.hsr.it

We have studied fasting plasma tryptophan (TRP) levels and tryptophan/large neutral amino acid (TRP/LNAA) ratios in 12 patients with obsessive-compulsive disorder (OCD) and 12 patients with OCD and a coexisting current diagnosis of major depressive disorder (OCD-MDD). Assessments were made at baseline and after 6 weeks of treatment with fluvoxamine. OCD-MDD patients had significantly lower baseline TRP levels and TRP/LNAA ratios than OCD patients. After 6 weeks of fluvoxamine treatment, OCD-MDD patients had significant increases in plasma TRP and TRP/LNAA ratio, whereas OCD patients had non-significant decreases. Our data suggest that a major depressive syndrome could be a state variable affecting the changes in plasma TRP and TRP/LNAA ratio in OCD patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009771 Obsessive-Compulsive Disorder An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension. Anankastic Personality,Neurosis, Obsessive-Compulsive,Anankastic Personalities,Disorder, Obsessive-Compulsive,Disorders, Obsessive-Compulsive,Neuroses, Obsessive-Compulsive,Neurosis, Obsessive Compulsive,Obsessive Compulsive Disorder,Obsessive-Compulsive Disorders,Obsessive-Compulsive Neuroses,Obsessive-Compulsive Neurosis,Personalities, Anankastic,Personality, Anankastic
D003866 Depressive Disorder An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent. Depression, Endogenous,Depression, Neurotic,Depression, Unipolar,Depressive Syndrome,Melancholia,Neurosis, Depressive,Unipolar Depression,Depressions, Endogenous,Depressions, Neurotic,Depressions, Unipolar,Depressive Disorders,Depressive Neuroses,Depressive Neurosis,Depressive Syndromes,Disorder, Depressive,Disorders, Depressive,Endogenous Depression,Endogenous Depressions,Melancholias,Neuroses, Depressive,Neurotic Depression,Neurotic Depressions,Syndrome, Depressive,Syndromes, Depressive,Unipolar Depressions
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D014364 Tryptophan An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals. Ardeydorm,Ardeytropin,L-Tryptophan,L-Tryptophan-ratiopharm,Levotryptophan,Lyphan,Naturruhe,Optimax,PMS-Tryptophan,Trofan,Tryptacin,Tryptan,Tryptophan Metabolism Alterations,ratio-Tryptophan,L Tryptophan,L Tryptophan ratiopharm,PMS Tryptophan,ratio Tryptophan
D016666 Fluvoxamine A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS. DU-23000,Desiflu,Dumirox,Faverin,Fevarin,Floxyfral,Fluvoxadura,Fluvoxamin AL,Fluvoxamin Stada,Fluvoxamin beta,Fluvoxamin-neuraxpharm,Fluvoxamin-ratiopharm,Fluvoxamina Geminis,Fluvoxamine Maleate,Fluvoxamine Maleate, (E)-Isomer,Fluvoxamine, (Z)-Isomer,Luvox,Novo-Fluvoxamine,Nu-Fluvoxamine,PMS-Fluvoxamine,ratio-Fluvoxamine,DU 23000,DU23000,Fluvoxamin neuraxpharm,Fluvoxamin ratiopharm,Geminis, Fluvoxamina,Novo Fluvoxamine,Nu Fluvoxamine,PMS Fluvoxamine,ratio Fluvoxamine

Related Publications

L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Plasma tryptophan levels and plasma tryptophan/neutral amino acids ratio in patients with mood disorder, patients with obsessive-compulsive disorder, and normal subjects.
November 1992, Psychiatry research,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Plasma tryptophan to large neutral amino acid ratios in depressed and normal subjects.
May 1990, Journal of affective disorders,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Plasma L-tryptophan/neutral amino acid ratio and dexamethasone suppression in depression.
March 1984, Psychiatry research,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Age dependence of large neutral amino acid levels in plasma. Focus on Tryptophan.
January 1996, Advances in experimental medicine and biology,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Plasma ratios of tryptophan and tyrosine to other large neutral amino acids in manic-depressive patients.
September 1992, The Japanese journal of psychiatry and neurology,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Plasma clomipramine levels in adult patients with obsessive-compulsive disorder.
January 2012, International clinical psychopharmacology,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Plasma tryptophan and total neutral amino acid levels in men: influence of hyperinsulinemia and age.
July 1987, Metabolism: clinical and experimental,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Decreased plasma tryptophan and tryptophan/large neutral amino acid ratio in patients with neuroleptic-resistant schizophrenia: relationship to plasma cortisol concentration.
February 2011, Psychiatry research,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
PET imaging in obsessive compulsive disorder with and without depression.
April 1990, The Journal of clinical psychiatry,
L Bellodi, and S Erzegovesi, and L Bianchi, and V Lucini, and R Conca, and A Lucca
Breakfast meal composition influences plasma tryptophan to large neutral amino acid ratios of healthy lean young men.
January 1985, Journal of neural transmission,
Copied contents to your clipboard!