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Apolipoprotein (apo)B mRNA editing is a novel mechanism for the post-transcriptional regulation of gene expression in mammals. It consists of a C-->U conversion of the first base of the codon CAA, encoding glutamine-2153, to UAA, an in-frame stop codon, in apoB mRNA. Since its initial description in 1987, substantial progress has been made in the last few years on the mechanism of editing. Apobec-1, the catalytic component of the apoB mRNA editing enzyme complex, has been cloned. This article begins with an overview of the general biology of apoB mRNA editing. It then provides an in-depth analysis of the structure, evolution and possible mechanism of action of apobec-1. ApoB mRNA editing is the prototype of RNA editing in mammals. What we learn from apoB mRNA editing will be useful in our understanding of other examples of RNA editing in vertebrates which are being described with increasing frequency.
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
October 1999,
Experimental cell research,
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
April 1996,
The Journal of biological chemistry,
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
July 2000,
The Journal of biological chemistry,
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
March 1995,
RNA (New York, N.Y.),
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
January 2002,
RNA (New York, N.Y.),
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
October 1997,
The Journal of biological chemistry,
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
October 1999,
The Journal of nutrition,
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
January 2003,
The Biochemical journal,
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
July 2001,
Experimental cell research,
L Chan, and
B H Chang, and
M Nakamuta, and
W H Li, and
L C Smith
January 2000,
Nucleic acids research,
