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Unidirectional fluxes of bicarbonate across the corneal endothelium were determined. A net flux of bicarbonate from the stromal to aqueous-facing surface was demonstrated. Under conditions of carbonic anhydrase inhibition the net bicarbonate flux was reduced by 54 percent and the passive water permeability of the endothelium was increased. Experiments with the specular microscope demonstrated an increased rate of corneal swelling under conditions of carbonic anhydrase inhibition. Attempts to identify H+ as the cation moving with the bicarbonate ion to maintain electroneutrality were not successful because of the impossibility of sustaining a differential H+ concentration difference across the endothelium.
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
April 2014,
Investigative ophthalmology & visual science,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
May 1990,
Experimental eye research,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
October 1981,
Investigative ophthalmology & visual science,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
October 2011,
Investigative ophthalmology & visual science,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
January 1991,
Transactions of the American Ophthalmological Society,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
March 2008,
Investigative ophthalmology & visual science,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
January 1984,
Annals of the New York Academy of Sciences,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
December 1980,
Acta ophthalmologica,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
May 1987,
Current eye research,
D S Hull, and
K Green, and
M Boyd, and
H R Wynn
April 1976,
Pflugers Archiv : European journal of physiology,
