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The systemic and local (intraocular) IgE antibody responses to infective and heat-killed Ascaris suum larvae were examined in guinea pigs. IgE antibody, demonstrated by the 6-day P-K test, was found in anterior chamber fluid following primary intravitreal injection of live second-stage A. suum larvae and in some instances occurred when no serum P-K activity was demonstrable. No intraocular IgE antibody was induced by primary intravitreal injection of heat-killed larvae. A brisk intraocular and systemic IgE antibody response followed the secondary intravitreal injection of either live or heat-killed larvae into animals systemically infected with A. suum. The guinea pig system promises to be a useful model for studying the immunopathology of human ocular parasite infections.
J J Donnelly, and
J H Rockey, and
E J Soulsby
January 1992,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
J J Donnelly, and
J H Rockey, and
E J Soulsby
January 1971,
Journal of immunology (Baltimore, Md. : 1950),
J J Donnelly, and
J H Rockey, and
E J Soulsby
May 1984,
American journal of veterinary research,
J J Donnelly, and
J H Rockey, and
E J Soulsby
January 1986,
Wiadomosci parazytologiczne,
J J Donnelly, and
J H Rockey, and
E J Soulsby
November 1979,
Immunology,
J J Donnelly, and
J H Rockey, and
E J Soulsby
June 1982,
Nordisk veterinaermedicin,
J J Donnelly, and
J H Rockey, and
E J Soulsby
July 1979,
Immunology,
J J Donnelly, and
J H Rockey, and
E J Soulsby
October 1985,
Experimental parasitology,
J J Donnelly, and
J H Rockey, and
E J Soulsby
January 1992,
International archives of allergy and immunology,
J J Donnelly, and
J H Rockey, and
E J Soulsby
January 1989,
Wiadomosci parazytologiczne,
