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This study examined in conscious dogs, the coronary and regional myocardial effects of bradykinin (BK) administered by intracoronary route and their modulation by an angiotensin-converting enzyme inhibitor. Eleven dogs were chronically instrumented with a left ventricular (LV) micromanometer, a circumflex coronary catheter, a flow probe, and ultrasonic crystals in the LV posterior wall. In the absence of systemic hemodynamic changes, BK (0.1-10 ng/kg i.c.) produced dose-dependent increases in coronary blood flow velocity (CBFV) and in LV posterior end-diastolic wall thickness (EDWT) but produced no change in LV regional myocardial function as assessed by LV posterior systolic wall thickening. The increases in LV EDWT and CBFV were linearly correlated. The BK B2 antagonist (HOE 140) abolished the effects of BK. Intracoronary enalaprilat (0.75 mg) extended the duration of the effect of BK on CBFV without modification of peak responses and induced a further increase in LV posterior EDWT but no change in LV regional myocardial function. Thus, in conscious dogs, the vasodilator effect of intracoronary BK alone or modulated by enalaprilat is not associated with changes in LV regional myocardial function.
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
January 1987,
The American journal of physiology,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
February 1985,
Circulation research,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
December 1987,
European journal of pharmacology,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
January 1997,
Fundamental & clinical pharmacology,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
May 1976,
The Journal of clinical investigation,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
August 1977,
The Journal of clinical investigation,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
January 1984,
Clinical and experimental hypertension. Part A, Theory and practice,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
November 1984,
The American journal of physiology,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
June 1984,
The Journal of pharmacology and experimental therapeutics,
R Houel, and
J Su, and
F Barbe, and
R Choussat, and
B Crozatier, and
L Hittinger
September 1981,
American heart journal,
