Pharmacological modulation of the cardiovascular response to hypertonic NaCl injection in the anteroventral area of the rat brain third ventricle. 1997

F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
Department of Pharmacology, J.M. Vargas School of Medicine, San José, Caracas, Venezuela.

The anteroventral area of the rat brain third ventricle (AV3V) was stimulated by stereotaxically placed microinjections (1 microliter) of hypertonic 1.5 mol/l NaCl and the responses of mean arterial pressure (MAP) and heart rate (HR) were recorded. Previous injection of terazosin or propranolol (5.0 micrograms) into AV3V, 15 min before 1.5 mol/l NaCl microinjection, did not alter the cardiovascular response pattern induced by 1.5 mol/l NaCl. Prior AV3V treatment with ketanserin (1.0 microgram) significantly reduced (p < 0.01) the MAP and HR increase induced by 1.0 microliter of 1.5 mol/l NaCl without changing basal cardiovascular parameters. Prior AV3V treatment with losartan (10.0 micrograms) significantly reduced (p < 0.01) the hypertension and tachycardia induced by hypertonic NaCl administration. Thus, AV3V serotonin and angiotensin II-sensitive neurons may exert an excitatory role on blood pressure and HR involved with the sympathetic discharge produced by hypertonic NaCl stimulation.

UI MeSH Term Description Entries
D007276 Injections, Intraventricular Injections into the cerebral ventricles. Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D008297 Male Males
D011943 Receptors, Adrenergic, beta One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. Adrenergic beta-Receptor,Adrenergic beta-Receptors,Receptors, beta-Adrenergic,beta Adrenergic Receptor,beta-Adrenergic Receptor,beta-Adrenergic Receptors,Receptor, Adrenergic, beta,Adrenergic Receptor, beta,Adrenergic beta Receptor,Adrenergic beta Receptors,Receptor, beta Adrenergic,Receptor, beta-Adrenergic,Receptors, beta Adrenergic,beta Adrenergic Receptors,beta-Receptor, Adrenergic,beta-Receptors, Adrenergic
D011945 Receptors, Angiotensin Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells. Angiotensin Receptor,Angiotensin Receptors,Angiotensin II Receptor,Angiotensin III Receptor,Receptor, Angiotensin II,Receptor, Angiotensin III,Receptor, Angiotensin
D011985 Receptors, Serotonin Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action. 5-HT Receptor,5-HT Receptors,5-Hydroxytryptamine Receptor,5-Hydroxytryptamine Receptors,Receptors, Tryptamine,Serotonin Receptor,Serotonin Receptors,Tryptamine Receptor,Tryptamine Receptors,Receptors, 5-HT,Receptors, 5-Hydroxytryptamine,5 HT Receptor,5 HT Receptors,5 Hydroxytryptamine Receptor,5 Hydroxytryptamine Receptors,Receptor, 5-HT,Receptor, 5-Hydroxytryptamine,Receptor, Serotonin,Receptor, Tryptamine,Receptors, 5 HT,Receptors, 5 Hydroxytryptamine
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D000803 Angiotensin I A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
January 2005, Autonomic neuroscience : basic & clinical,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
March 1987, Brain research,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
June 1986, Neuroscience letters,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
February 1974, The American journal of physiology,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
October 1982, The American journal of physiology,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
December 1986, Brain research bulletin,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
September 1984, The American journal of physiology,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
July 1974, The American journal of physiology,
F Rosa, and J Vásquez, and J Lupi, and E Lezama, and E Romero-Vecchione
June 2005, American journal of physiology. Regulatory, integrative and comparative physiology,
Copied contents to your clipboard!