BIOMAT Database Logo BIOMAT Database Logo

Risk factors for adverse cutaneous reactions associated with intravenous vancomycin. 1997

T M Korman, and J D Turnidge, and M L Grayson
Department of Infectious Diseases and Microbiology, Monash Medical Centre, Clayton, VIC, Australia.

We retrospectively studied adverse cutaneous reactions associated with intravenous vancomycin therapy over a 14-month period when two different brands of vancomycin were used. Of 224 adults, 12 (5.4%) had infusion-related reactions; ten of 174 patients who received more than one day of vancomycin (5.7%) had delayed cutaneous reactions. Age less than 40 years was a risk factor for both infusion-related and delayed reactions by both univariate and multivariate analysis. Duration of therapy greater than 7 days was a risk factor for delayed reactions. There was a significant increase in adverse cutaneous reactions associated with the use of a particular batch of vancomycin, although analytical testing of this batch failed to identify any difference from other batches associated with routine rates of adverse reactions. Awareness of vancomycin-associated infusion-related and delayed cutaneous reactions is necessary, and the risk factors associated with these reactions may have important clinical implications.

UI MeSH Term Description Entries
D007262 Infusions, Intravenous The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it. Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003875 Drug Eruptions Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions. Dermatitis Medicamentosa,Dermatitis, Adverse Drug Reaction,Maculopapular Drug Eruption,Maculopapular Exanthem,Morbilliform Drug Reaction,Morbilliform Exanthem,Drug Eruption,Drug Eruption, Maculopapular,Drug Eruptions, Maculopapular,Drug Reaction, Morbilliform,Drug Reactions, Morbilliform,Eruption, Drug,Eruption, Maculopapular Drug,Eruptions, Drug,Eruptions, Maculopapular Drug,Exanthem, Maculopapular,Exanthem, Morbilliform,Exanthems, Maculopapular,Exanthems, Morbilliform,Maculopapular Drug Eruptions,Maculopapular Exanthems,Morbilliform Drug Reactions,Morbilliform Exanthems,Reaction, Morbilliform Drug,Reactions, Morbilliform Drug
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial

Related Publications

T M Korman, and J D Turnidge, and M L Grayson
Vancomycin-associated spontaneous cutaneous adverse drug reactions.
July 2011, Allergy, asthma & immunology research,
T M Korman, and J D Turnidge, and M L Grayson
Incidence of teicoplanin adverse drug reactions among patients with vancomycin-associated adverse drug reactions and its risk factors.
May 2020, The Korean journal of internal medicine,
T M Korman, and J D Turnidge, and M L Grayson
Genetic factors associated with severe cutaneous adverse reactions.
November 2014, JAMA,
T M Korman, and J D Turnidge, and M L Grayson
Genetic factors associated with severe cutaneous adverse reactions--reply.
November 2014, JAMA,
T M Korman, and J D Turnidge, and M L Grayson
Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions.
August 2016, Current opinion in allergy and clinical immunology,
T M Korman, and J D Turnidge, and M L Grayson
Risk factors for sulfamethoxazole/trimethoprim-induced severe cutaneous adverse reactions.
May 2024, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
T M Korman, and J D Turnidge, and M L Grayson
Risk factors for adverse drug reactions associated with clopidogrel therapy.
January 2022, Open medicine (Warsaw, Poland),
T M Korman, and J D Turnidge, and M L Grayson
Risk Factors Associated With Nephrotoxicity During Outpatient Intravenous Vancomycin Administration.
February 2022, The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians,
T M Korman, and J D Turnidge, and M L Grayson
Risk factors associated with adverse reactions to antituberculosis drugs.
January 2015, Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia,
T M Korman, and J D Turnidge, and M L Grayson
Genetic and clinical risk factors associated with phenytoin-induced cutaneous adverse drug reactions in Thai population.
May 2020, Pharmacoepidemiology and drug safety,
Copied contents to your clipboard!