Biomaterial Database

A paper chromatographic method for separation and determination of synephrine in injectable solutions. 1977

A E El-Nimr, and H O Ammar, and H A Salama

A new analytical method using ascending paper chromatographic technique was developed for identification and quantitative determination of residual synephrine in fresh and deteriorated samples. This method was found to be stability indicating; one to five degradation products have been successfully separated from drug samples subjected to accelerated stability testing at 60 degrees C for 3 months.

UI	MeSH Term	Description	Entries
D007202	Indicators and Reagents	Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)	Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D007267	Injections	Introduction of substances into the body using a needle and syringe.	Injectables,Injectable,Injection
D002854	Chromatography, Paper	An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).	Paper Chromatography,Chromatographies, Paper,Paper Chromatographies
D013578	Synephrine	Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.	Sympaethamin,Oxedrine,Synephrin