BIOMAT Database Logo BIOMAT Database Logo

Response to hypercapnia in moyamoya disease. Cerebrovascular response to hypercapnia in pediatric and adult patients with moyamoya disease. 1997

Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

OBJECTIVE We have previously reported that cerebral blood flow decreased and oxygen extraction fraction and cerebral blood volume increased in pediatric patients with moyamoya disease, whereas these values did not change significantly in adult patients. In this study, we measured the cerebrovascular response to hypercapnia using 15O H2O positron emission tomography (PET) in each group of patients. These data were also compared with the oxygen extraction fraction and transit time (cerebral blood volume/cerebral blood flow) measured by 15O PET. METHODS The subjects consisted of 20 patients with moyamoya disease (7 pediatric and 13 adult patients). Cerebral blood flow was measured by the 15O H2O bolus injection method at the resting state and during the inhalation of 5% CO2. Cerebrovascular CO2 response was estimated as the percentage change of cerebral blood flow per 1 mm Hg change of PaCO2. Oxygen extraction fraction and transit time were measured by the 15O steady-state method. RESULTS Cerebrovascular response to hypercapnia severely decreased over the cerebral cortices in both pediatric and adult patients with moyamoya disease when compared with those of normal control subjects, and there was no significant difference between pediatric and adult patients. A significant correlation was observed between the CO2 response and transit time, whereas no significant correlation was seen between the CO2 response and oxygen extraction fraction. CONCLUSIONS Our study revealed that the cerebral hemodynamic reserve capacity decreased to an equal degree in both pediatric and adult patients with moyamoya disease. This finding may thus help to explain the occurrence of transient ischemic attack in adult patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009072 Moyamoya Disease A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults. Cerebrovascular Moyamoya Disease,Progressive Intracranial Occlusive Arteropathy (Moyamoya),Moya-Moya Disease,Moyamoya Disease, Classic,Moyamoya Disease, Primary,Moyamoya Disease, Secondary,Moyamoya Syndrome,Classic Moyamoya Disease,Disease, Classic Moyamoya,Disease, Moya-Moya,Disease, Primary Moyamoya,Moya Moya Disease,Moyamoya Diseases, Primary,Primary Moyamoya Disease,Primary Moyamoya Diseases,Secondary Moyamoya Disease
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D001810 Blood Volume Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME. Blood Volumes,Volume, Blood,Volumes, Blood
D002546 Ischemic Attack, Transient Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6) Brain Stem Ischemia, Transient,Cerebral Ischemia, Transient,Crescendo Transient Ischemic Attacks,Transient Ischemic Attack,Anterior Circulation Transient Ischemic Attack,Brain Stem Transient Ischemic Attack,Brain TIA,Brainstem Ischemia, Transient,Brainstem Transient Ischemic Attack,Carotid Circulation Transient Ischemic Attack,Posterior Circulation Transient Ischemic Attack,TIA (Transient Ischemic Attack),Transient Ischemic Attack, Anterior Circulation,Transient Ischemic Attack, Brain Stem,Transient Ischemic Attack, Brainstem,Transient Ischemic Attack, Carotid Circulation,Transient Ischemic Attack, Posterior Circulation,Transient Ischemic Attack, Vertebrobasilar Circulation,Transient Ischemic Attacks, Crescendo,Vertebrobasilar Circulation Transient Ischemic Attack,Attack, Transient Ischemic,Attacks, Transient Ischemic,Brainstem Ischemias, Transient,Cerebral Ischemias, Transient,Ischemia, Transient Brainstem,Ischemia, Transient Cerebral,Ischemias, Transient Brainstem,Ischemias, Transient Cerebral,Ischemic Attacks, Transient,TIA, Brain,TIAs (Transient Ischemic Attack),Transient Brainstem Ischemia,Transient Cerebral Ischemia,Transient Cerebral Ischemias,Transient Ischemic Attacks
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Cerebrovascular autoregulation in pediatric moyamoya disease.
June 2013, Paediatric anaesthesia,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Cerebrovascular collaterals correlate with disease severity in adult North American patients with Moyamoya disease.
July 2014, AJNR. American journal of neuroradiology,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Letter: Cerebrovascular response to hypercapnia.
July 1976, Lancet (London, England),
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Cortical blood flow response to hypercapnia during anaesthesia in Moyamoya disease.
August 1993, Canadian journal of anaesthesia = Journal canadien d'anesthesie,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Cerebrovascular "Moyamoya" disease.
January 1973, Proceedings of the Australian Association of Neurologists,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Cerebrovascular Moyamoya disease.
March 1974, British medical journal,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Cerebrovascular Moyamoya disease.
April 1984, European journal of pediatrics,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Cerebrovascular response of arteriosclerotic patients to hypercapnia during general anesthesia.
January 1966, Acta anaesthesiologica Scandinavica. Supplementum,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Human cerebrovascular response to combined hypoxia and hypercapnia.
November 1966, Circulation research,
Y Kuwabara, and Y Ichiya, and M Sasaki, and T Yoshida, and K Masuda, and T Matsushima, and M Fukui
Moyamoya disease causing recurrent cerebrovascular episodes in a young adult.
April 1987, The Medical journal of Australia,
Copied contents to your clipboard!