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In order to study the role of Fos on the regulation of proliferation in the monocyte-macrophage lineage we realized a stable transfection of the murine P388D1 cell line by the murine c-fos gene under the control of the human metallothionein IIA promoter. Several clones have been selected by geneticin: they show a variable number of integrated transgene (two to ten copies). Their expression has been analyzed in the presence or absence of cadmium chloride as inducer (5 x 10(-6) M). In one clone especially, the c-fos mRNA and Fos protein levels were respectively 6- and 10-fold increased. The study of cell growth by tritiated thymidine incorporation indicates a negative effect of the overexpressed Fos protein in the absence of any other stimulus.
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
January 1992,
Developments in biological standardization,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
March 2001,
European cytokine network,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
October 1995,
The Kobe journal of medical sciences,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
January 1991,
Oncogene,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
August 1987,
European journal of cell biology,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
April 1997,
Cytokine,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
September 2008,
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
September 2000,
International journal of immunopharmacology,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
October 2004,
International immunology,
R Mirahmadi, and
Y Le Garrec, and
E Rouer, and
P Michel, and
A Pompidou
January 1992,
Immunopharmacology and immunotoxicology,
