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The purpose of this study was to examine the effects of short-term caloric restriction (CR) for 4, 8 and 16 weeks on gastric acid secretion in rats. CR rats fed 60% of normal food intake for 4, 8 or 16 weeks and then prepared with gastric fistulas. Histamine- and carbachol-stimulated gastric acid secretion were significantly (P < 0.05) decreased after more than 4 weeks and 8 weeks of caloric restriction, respectively. In contrast, gastrin-stimulated acid secretion was unaffected by CR. The 1-h-integrated acid output to a submaximal dose of gastrin (40 micrograms.kg-1) was significantly higher than that of histamine (5 mg.kg-1) after 8 weeks of CR (63 +/- 13 and 27 +/- 4 microEq.h-1, respectively). Gastrin treatment (5 micrograms.kg-1.h-1) of CR rats restored the gastric acid responses to both histamine and carbachol. These results suggest that CR can selectively decrease the gastric acid responses to both histamine and carbachol by depletion of the endogenous tissue stores of gastrin. More importantly, these results indicate that under an in vivo gastrin-diminished condition, histamine is not the final secretagogue for gastric acid secretion.
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
October 1991,
The American journal of physiology,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
January 1982,
Acta physiologica Academiae Scientiarum Hungaricae,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
January 1974,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
January 2017,
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
April 1988,
The American journal of physiology,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
January 1951,
Acta - Unio Internationalis Contra Cancrum,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
December 1984,
Canadian journal of physiology and pharmacology,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
January 2019,
Frontiers in physiology,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
June 2006,
Biogerontology,
S Higashide, and
K U Chu, and
G Gomez, and
G H Greeley, and
J C Thompson, and
C M Townsend
January 2003,
Mechanisms of ageing and development,
