-transparent.png){kind=logo}
OBJECTIVE To investigate whether glucagon increases the urinary excretion of oxypurinol and purine bases. METHODS We administered 1 mg glucagon intravenously to 5 healthy subjects taking 300 mg allopurinol orally, and determined plasma concentrations and urinary excretion of oxypurinol and purine bases. RESULTS Glucagon increased the urinary excretion and fractional clearances of uric acid, xanthine, and oxypurinol, together with an increase in creatinine clearance, while it decreased plasma concentrations of xanthine and hypoxanthine. CONCLUSIONS Glucagon-induced increases in urinary excretion of uric acid, xanthine, and oxypurinol were attributable to increases in the fractional clearances of uric acid, xanthine, and oxypurinol in addition to an increase in glomerular filtration rate. It is suggested that glucagon affects the renal common transport pathway of uric acid, xanthine, and oxypurinol by stimulating the release of a liver derived renal vasodilator.
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
July 1959,
Archives internationales de pharmacodynamie et de therapie,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
February 1952,
Doklady Akademii nauk SSSR,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
July 1964,
The British journal of psychiatry : the journal of mental science,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
January 1993,
Renal failure,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
March 1960,
Pharmacological reviews,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
January 1990,
The British journal of nutrition,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
January 1969,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
September 1990,
Zeitschrift fur Ernahrungswissenschaft,
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
July 1974,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
T Yamamoto, and
Y Moriwaki, and
S Takahashi, and
Z Tsutsumi, and
K Hiroishi, and
J Yamakita, and
T Nakano, and
K Higashino
April 1967,
Metabolism: clinical and experimental,
