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Fifty-four untreated, mildly hypertensive men who were civil servants and were aged 30-59 years reduced their alcohol consumption as much as possible for three weeks. Then blood pressure and serum gamma GTP decreased significantly, but Na(+)-K(+)-ATPase activity of the red blood cell membrane did not change significantly. The enzyme activity in twenty subjects (45.5% of total subjects) increased and that in twenty-four subjects (54.5%) decreased or was unchanged. No significant relationship between the ratio of the change of Na(+)-K(+)-ATPase activity and that of blood pressure or serum gamma GTP was observed.
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