Nephrotic proteinuria in acute poststreptococcal glomerulonephritis is rare. In 62 patients aging from 18 to 22 years, proteinuria of > 3 g/24 hrs was found ins 5 (8%) patients, 0.3 to 3 g/24 hrs in 36 (58%) and 0.15 to 0.3 g/24 hrs in 21 (34%) patients. Proteinuria in many patients disappeared after 3 months and in later follow up it was found in about 30% of patients. Out of 5 patients with proteinuria of > 3 g/24 hrs 3 had persistent pathological urinary analysis, 2 patients were rebiopsied after 5 and 3 years from the disease onset, the morphological changes were moderate. In 2 patients after acute phase had been over came to the clinical healthy (with normal urinary analysis) lasting for 2 years and in the rebiopsy less marked pathological changes were described. Immunofluorescent analysis in the all patients were negative. Patients with initial nephrotic proteinuria in poststreptococcal glomerulonephritis have bad prognosis and often develop chronic disease.