Biomaterial Database

[Chemonucleolysis of lumbar disk prolapse. Choice and complications]. 1997

R Salvesen, and S Hemminghytt

Neurologisk avdeling, Nordland Sentralsykehus, Bodø.

Chemonucleolysis with chymopapain is a well-documented method of treating lumbar disc herniation. In spite of this, only few patients are treated in this way in Norway. We have offered selected patients chemonucleolysis at our hospital since 1985. This article reports the long-term outcomes as regards employment status, back pain and leg pain. We have treated 277 patients. 269 were still alive in October 1995 and were sent a follow-up questionnaire. 257 patients responded, of whom 36 (14%) had undergone surgery later, due to an unsatisfactory outcome of chemonucleolysis. 72% of the patients were fully employed at the time of follow-up. 61% had little or no back pain, while 69% never or only rarely suffered pain in the leg.

UI	MeSH Term	Description	Entries
D007404	Intervertebral Disc Chemolysis	The dissolving of the NUCLEUS PULPOSUS, the semi-gelatinous tissue of a displaced INTERVERTEBRAL DISC. It is usually achieved by the direct injection of a proteolytic enzyme, especially CHYMOPAPAIN, into the herniated disc.	Chemolysis, Intervertebral Disk,Chemonucleolysis,Discolysis,Intervertebral Disk Chemolysis,Nucleolysis, Intervertebral Disk,Chemolysis, Intervertebral Disc,Nucleolysis, Intervertebral Disc,Chemolyses, Intervertebral Disc,Chemolyses, Intervertebral Disk,Chemonucleolyses,Discolyses,Intervertebral Disc Chemolyses,Intervertebral Disc Nucleolyses,Intervertebral Disc Nucleolysis,Intervertebral Disk Chemolyses,Intervertebral Disk Nucleolyses,Intervertebral Disk Nucleolysis,Nucleolyses, Intervertebral Disc,Nucleolyses, Intervertebral Disk
D007405	Intervertebral Disc Displacement	An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region.	Disc Herniation,Disc Protrusion,Disc, Herniated,Disk Herniation,Disk Protrusion,Disk, Herniated,Intervertebral Disc Herniation,Intervertebral Disc Protrusion,Intervertebral Disk Displacement,Intervertebral Disk Herniation,Intervertebral Disk Protrusion,Prolapsed Disk,Protruded Disc,Protruded Disk,Slipped Disk,Disk Prolapse,Herniated Disc,Herniated Disk,Prolapsed Disc,Slipped Disc,Disc Displacement, Intervertebral,Disc Herniations,Disc Protrusion, Intervertebral,Disc Protrusions,Disc Protrusions, Intervertebral,Disc, Prolapsed,Disc, Protruded,Disc, Slipped,Discs, Protruded,Disk Displacement, Intervertebral,Disk Herniations,Disk Prolapses,Disk Protrusion, Intervertebral,Disk Protrusions,Disk, Prolapsed,Disk, Protruded,Disk, Slipped,Herniated Discs,Herniated Disks,Herniation, Disc,Herniation, Disk,Herniation, Intervertebral Disc,Herniation, Intervertebral Disk,Intervertebral Disc Displacements,Intervertebral Disc Herniations,Intervertebral Disc Protrusions,Intervertebral Disk Displacements,Intervertebral Disk Herniations,Intervertebral Disk Protrusions,Prolapse, Disk,Prolapsed Discs,Prolapsed Disks,Prolapses, Disk,Protruded Discs,Protruded Disks,Protrusion, Disc,Protrusion, Disk,Protrusion, Intervertebral Disc,Protrusion, Intervertebral Disk,Protrusions, Intervertebral Disk,Slipped Discs,Slipped Disks
D011795	Surveys and Questionnaires	Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions.	Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D002917	Chymopapain	A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic acid residues. EC 3.4.22.6.	Chemolase,Chymodiactin,Chymopapain A,Chymopapain B,Discase
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D017060	Patient Satisfaction	The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.	Satisfaction, Patient