Biomaterial Database

Neuroleptic malignant syndrome associated with severe thrombocytopenia. 1997

J G Ray

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

The case of a 32-year-old woman with neuroleptic malignant syndrome and severe haemorrhagic thrombocytopenia is presented. Detailed investigations were negative, and the thrombocytopenia resolved along with her fever, obtundation, autonomic instability and oculogyric crisis. No prior similar cases have been described in the literature. A discussion of neuroleptic malignant syndrome and neuroleptic-related thrombocytopenia follows, in addition to the possible mechanisms of the thrombocytopenia in this case.

UI	MeSH Term	Description	Entries
D009459	Neuroleptic Malignant Syndrome	A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)	Neuroleptic-Induced Neuroleptic Malignant Syndrome,Neuroleptic-Malignant Syndrome, Neuroleptic Induced,NMS (Neuroleptic Malignant Syndrome),NMSs (Neuroleptic Malignant Syndrome),Neuroleptic Induced Neuroleptic Malignant Syndrome,Neuroleptic Malignant Syndrome, Neuroleptic Induced,Neuroleptic Malignant Syndromes,Syndrome, Neuroleptic Malignant,Syndromes, Neuroleptic Malignant
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012720	Severity of Illness Index	Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.	Illness Index Severities,Illness Index Severity
D013921	Thrombocytopenia	A subnormal level of BLOOD PLATELETS.	Thrombopenia,Thrombocytopenias,Thrombopenias