-transparent.png){kind=logo}
1. Cyclohexanecarboxylic acid in isolated perfused rat livers was eliminated from the perfusion system by a first-order process. 2. After 6 h, 16% was excreted in bile as cyclohexylcarbonyl beta-D-glucuronide. The remainder was present in the perfusate as unchanged cyclohexanecarboxylic acid (10%), hippuric acid (50%), hexahydrohippuric acid (2%), 3,4,5,6-tetrahydrohippuric acid (2%), cyclohexylcarbonyl-beta-D-glucuronide (2-4%) and benzoic acid (1-2%). Six per cent of the dose was associated with the red blood cell present in the perfusion medium. 3. Unlike the whole animal, the isolated rat liver produced no detectable benzoyl glucuronide. 4. The identity and kinetics of production of the metabolites are consistent with a metabolic pathway previously proposed for cyclohexanecarboxylic acid and shikimic acid.
D Brewster, and
R S Jones, and
D V Parke
July 1990,
The Journal of surgical research,
D Brewster, and
R S Jones, and
D V Parke
July 1971,
The Journal of physiology,
D Brewster, and
R S Jones, and
D V Parke
December 1993,
Planta medica,
D Brewster, and
R S Jones, and
D V Parke
March 1974,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
D Brewster, and
R S Jones, and
D V Parke
July 1965,
Annals of the New York Academy of Sciences,
D Brewster, and
R S Jones, and
D V Parke
December 2012,
Phytotherapy research : PTR,
D Brewster, and
R S Jones, and
D V Parke
January 1957,
The Journal of clinical endocrinology and metabolism,
D Brewster, and
R S Jones, and
D V Parke
January 1989,
Contributions to nephrology,
D Brewster, and
R S Jones, and
D V Parke
July 1965,
The Journal of pharmacology and experimental therapeutics,
D Brewster, and
R S Jones, and
D V Parke
June 1973,
The Biochemical journal,
