BIOMAT Database Logo BIOMAT Database Logo

Genotoxicity testing of an aqueous mistletoe extract in vitro. 1997

U Mengs, and C B Clare, and J A Poiley
Madaus AG, Cologne, Germany.

An aqueous mistletoe extract (AME, the active principle of Lektinol) was investigated for its genotoxic potential in a wide range of in vitro studies, according to the actual international standard guidelines. Gene mutation tests on bacteria and mammalian cells in vitro all gave negative results. From the findings of cytogenetic studies, there was no indication of a clastogenic activity in human lymphocytes. A cell transformation assay revealed no malignant changes of Syrian hamster embryo cell cultures. In summary, the results suggest that AME has no genotoxic potential in vitro.

UI MeSH Term Description Entries
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008297 Male Males
D008647 Mesocricetus A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research. Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D010946 Plants, Medicinal Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals. Herbs, Medicinal,Medicinal Herbs,Healing Plants,Medicinal Plants,Pharmaceutical Plants,Healing Plant,Herb, Medicinal,Medicinal Herb,Medicinal Plant,Pharmaceutical Plant,Plant, Healing,Plant, Medicinal,Plant, Pharmaceutical,Plants, Healing,Plants, Pharmaceutical
D003582 Cytogenetics A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE. Cytogenetic
D004926 Escherichia coli A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster

Related Publications

U Mengs, and C B Clare, and J A Poiley
Activation of dendritic cells by an aqueous mistletoe extract and mistletoe lectin-3 in vitro.
January 2002, Anticancer research,
U Mengs, and C B Clare, and J A Poiley
Biological effects of natural and recombinant mistletoe lectin and an aqueous mistletoe extract on human monocytes and lymphocytes in vitro.
January 2000, Journal of clinical laboratory analysis,
U Mengs, and C B Clare, and J A Poiley
Antiproliferative activity of an aqueous mistletoe extract in human tumor cell lines and xenografts in vitro.
September 2001, Arzneimittel-Forschung,
U Mengs, and C B Clare, and J A Poiley
The genotoxicity of an aqueous extract of Gyejibokryeong-hwan.
January 2018, BMC complementary and alternative medicine,
U Mengs, and C B Clare, and J A Poiley
Anticancer activity of an aqueous mistletoe extract (AME) in syngeneic murine tumor models.
January 2001, Anticancer research,
U Mengs, and C B Clare, and J A Poiley
Genotoxicity testing of a fenugreek extract.
November 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
U Mengs, and C B Clare, and J A Poiley
[An allergy to mistletoe extract].
August 1991, Deutsche medizinische Wochenschrift (1946),
U Mengs, and C B Clare, and J A Poiley
In vivo genotoxicity evaluation of an artichoke (Cynara scolymus L.) aqueous extract.
February 2013, Journal of food science,
U Mengs, and C B Clare, and J A Poiley
Phytochemical and In Vitro Genotoxicity Studies of Standardized Ficus deltoidea var. kunstleri Aqueous Extract.
February 2021, Plants (Basel, Switzerland),
U Mengs, and C B Clare, and J A Poiley
No evidence of stimulation of human tumor cell proliferation by a standardized aqueous mistletoe extract in vitro.
January 2003, Anticancer research,
Copied contents to your clipboard!