-transparent.png){kind=logo}
The fate of orally administered total 14C-labelled Escherichia coli extract (TEC, OM-89) was compared to that of its major 14C-labeled high molecular weight fractions (HEC, > 30 kD) in mice. High molecular weight substances (> 30 kD) were observed in blood 1 h after oral administration of the products, TEC and HEC. This suggests absorption from the digestive tract of the total E. coli extract. Blood clearance after 24 h indicates that the product was rapidly eliminated or taken up by the tissues. Its highest organ distribution among the measured organs was found in the liver, followed by the spleen and the Peyer's patches. Low molecular weight fractions (LEC, < 30 kD) were also used as control. This pilot study provides a rationale for in vivo pharmacological investigations with oral administration of the E. coli immunomodulating extract OM-89.
M F Burckhart, and
J Mimouni, and
R Fontanges
March 1997,
Arzneimittel-Forschung,
M F Burckhart, and
J Mimouni, and
R Fontanges
August 1981,
Food and cosmetics toxicology,
M F Burckhart, and
J Mimouni, and
R Fontanges
January 1976,
The British journal of nutrition,
M F Burckhart, and
J Mimouni, and
R Fontanges
January 1997,
European journal of drug metabolism and pharmacokinetics,
M F Burckhart, and
J Mimouni, and
R Fontanges
August 1997,
Arzneimittel-Forschung,
M F Burckhart, and
J Mimouni, and
R Fontanges
January 1998,
European journal of drug metabolism and pharmacokinetics,
M F Burckhart, and
J Mimouni, and
R Fontanges
February 1998,
Xenobiotica; the fate of foreign compounds in biological systems,
M F Burckhart, and
J Mimouni, and
R Fontanges
November 1987,
Il Farmaco; edizione pratica,
M F Burckhart, and
J Mimouni, and
R Fontanges
April 1970,
Zeitschrift fur Tierphysiologie, Tierernahrung und Futtermittelkunde,
M F Burckhart, and
J Mimouni, and
R Fontanges
January 2017,
The open medicinal chemistry journal,
