Biomaterial Database

Disconnection of medial agranular and posterior parietal cortex produces multimodal neglect in rats. 1997

K J Burcham, and J V Corwin, and M L Stoll, and R L Reep

Department of Psychology, Northern Illinois University, DeKalb 60115, USA. tj0jvcl@corn.cso.niu.edu

Two cortical areas in rats have been found to be important in directed attention and spatial processing: the medial agranular cortex (AGm), the rodent analog of the frontal eye fields; and the posterior parietal cortex (PPC), the rodent analog of area 7 in primates. As in primates, unilateral destruction of either of these cortical association areas produces severe contralesional neglect of visual, auditory, and tactile stimulation. AGm and PPC are reciprocally interconnected by longitudinally oriented axons traveling in layer VI of the cortex. Their trajectory provides a unique opportunity to examine the effects of disconnection of these two areas. The key question is whether these two regions function independently or as components of a cortical network for directed attention. Unilateral disconnection of the PPC and AGm was achieved via transverse knife-cuts extending through layer VI of cortex, and the disconnection verified by tract-tracing methods. The knife-cuts produced severe multimodal neglect and allesthesia/allokinesia. The deficits produced by the knife-cuts were virtually identical to those produced by unilateral destruction of these regions. The control operates, which received knife-cuts that spared the interconnections between the AGm and PPC, were unimpaired. The results indicate that AGm and PPC in rats function as parts of a cortical system for directed attention.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009434	Neural Pathways	Neural tracts connecting one part of the nervous system with another.	Neural Interconnections,Interconnection, Neural,Interconnections, Neural,Neural Interconnection,Neural Pathway,Pathway, Neural,Pathways, Neural
D009949	Orientation	Awareness of oneself in relation to time, place and person.	Cognitive Orientation,Mental Orientation,Psychological Orientation,Cognitive Orientations,Mental Orientations,Orientation, Cognitive,Orientation, Mental,Orientation, Psychological,Orientations,Orientations, Cognitive,Orientations, Mental,Orientations, Psychological,Psychological Orientations
D010296	Parietal Lobe	Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.	Brodmann Area 39,Brodmann Area 40,Brodmann Area 5,Brodmann Area 7,Brodmann's Area 39,Brodmann's Area 40,Brodmann's Area 5,Brodmann's Area 7,Inferior Parietal Cortex,Secondary Sensorimotor Cortex,Superior Parietal Lobule,Angular Gyrus,Gyrus Angularis,Gyrus Supramarginalis,Intraparietal Sulcus,Marginal Sulcus,Parietal Cortex,Parietal Lobule,Parietal Region,Posterior Paracentral Lobule,Posterior Parietal Cortex,Praecuneus,Precuneus,Precuneus Cortex,Prelunate Gyrus,Supramarginal Gyrus,Area 39, Brodmann,Area 39, Brodmann's,Area 40, Brodmann,Area 40, Brodmann's,Area 5, Brodmann,Area 5, Brodmann's,Area 7, Brodmann,Area 7, Brodmann's,Brodmanns Area 39,Brodmanns Area 40,Brodmanns Area 5,Brodmanns Area 7,Cortex, Inferior Parietal,Cortex, Parietal,Cortex, Posterior Parietal,Cortex, Precuneus,Cortex, Secondary Sensorimotor,Cortices, Inferior Parietal,Gyrus, Angular,Gyrus, Prelunate,Gyrus, Supramarginal,Inferior Parietal Cortices,Lobe, Parietal,Lobule, Parietal,Lobule, Posterior Paracentral,Lobule, Superior Parietal,Paracentral Lobule, Posterior,Paracentral Lobules, Posterior,Parietal Cortex, Inferior,Parietal Cortex, Posterior,Parietal Cortices,Parietal Cortices, Inferior,Parietal Cortices, Posterior,Parietal Lobes,Parietal Lobule, Superior,Parietal Lobules,Parietal Lobules, Superior,Parietal Regions,Posterior Paracentral Lobules,Posterior Parietal Cortices,Precuneus Cortices,Region, Parietal,Secondary Sensorimotor Cortices,Sensorimotor Cortex, Secondary,Superior Parietal Lobules
D001931	Brain Mapping	Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.	Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D004292	Dominance, Cerebral	Dominance of one cerebral hemisphere over the other in cerebral functions.	Cerebral Dominance,Hemispheric Specialization,Dominances, Cerebral,Specialization, Hemispheric
D005625	Frontal Lobe	The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.	Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001288	Attention	Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.	Focus of Attention,Selective Attention,Social Attention,Attention Focus,Attention, Selective,Attention, Social,Selective Attentions
D001307	Auditory Perception	The process whereby auditory stimuli are selected, organized, and interpreted by the organism.	Auditory Processing,Perception, Auditory,Processing, Auditory