-transparent.png){kind=logo}
Surface-modified human serum albumin (HSA) nanospheres with a size of around 100 nm in diameter were prepared from poly(amidoamine)-poly(ethylene glycol) copolymer grafted human serum albumin (HSA-PAA-PEG) and poly(thioetheramido acid)-poly(ethylene glycol) copolymer grafted human serum albumin (HSA-PTAAC-PEG). The nanospheres were produced using a pH-coacervation method and cross-linked with glutaraldehyde. The cross-linking efficiency was affected by the type of albumin conjugate used. The zeta potential of the surface-modified nanospheres was significantly lower than that of unmodified particles. The existence of a hydrated steric barrier surrounding the nanospheres was confirmed by electrolyte- and pH-induced flocculation tests. The surface-modified nanospheres showed a reduced plasma protein adsorption on the particle surface compared with unmodified particles.
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
October 2003,
Yao xue xue bao = Acta pharmaceutica Sinica,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
January 2008,
International journal of pharmaceutics,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
January 2011,
The Journal of pharmacy and pharmacology,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
December 1987,
Drug design and delivery,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
August 2012,
Chemical communications (Cambridge, England),
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
October 2016,
International journal of biological macromolecules,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
February 2014,
Artificial cells, nanomedicine, and biotechnology,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
July 1988,
Drug design and delivery,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
April 1999,
Drug development and industrial pharmacy,
W Lin, and
M C Garnett, and
M C Davies, and
F Bignotti, and
P Ferruti, and
S S Davis, and
L Illum
January 2022,
Journal of oncology,
