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We measured CSF levels of beta-endorphin, an opioid hormone, in 19 patients with infantile autism and in 3 patients with Rett syndrome, and compared them with control values. In infantile autism, CSF levels of beta-endorphin did not differ significantly from those of age-matched controls. There was no significant correlation between CSF levels and clinical symptoms, including self-injurious behavior, pain insensitivity, and stereotyped movement. However, CSF levels of beta-endorphin were significantly higher in the patients with Rett syndrome than in the control (p < .05). Data suggest that neurons containing beta-endorphin may not be involved in patients with infantile autism. Thus, there is no relationship between dysfunction of brain opioid and autism.
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T Matsuishi, and
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H Komori, and
M Miyazaki, and
T Hashimoto, and
Y Yamashita, and
E Ohtaki, and
H Kato
January 1987,
Pediatric neurology,
S Nagamitsu, and
T Matsuishi, and
T Kisa, and
H Komori, and
M Miyazaki, and
T Hashimoto, and
Y Yamashita, and
E Ohtaki, and
H Kato
January 1993,
The Kurume medical journal,
S Nagamitsu, and
T Matsuishi, and
T Kisa, and
H Komori, and
M Miyazaki, and
T Hashimoto, and
Y Yamashita, and
E Ohtaki, and
H Kato
August 1987,
Life sciences,
S Nagamitsu, and
T Matsuishi, and
T Kisa, and
H Komori, and
M Miyazaki, and
T Hashimoto, and
Y Yamashita, and
E Ohtaki, and
H Kato
July 1988,
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S Nagamitsu, and
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T Hashimoto, and
Y Yamashita, and
E Ohtaki, and
H Kato
September 1984,
Neurological research,
S Nagamitsu, and
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H Komori, and
M Miyazaki, and
T Hashimoto, and
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E Ohtaki, and
H Kato
May 1983,
Masui. The Japanese journal of anesthesiology,
S Nagamitsu, and
T Matsuishi, and
T Kisa, and
H Komori, and
M Miyazaki, and
T Hashimoto, and
Y Yamashita, and
E Ohtaki, and
H Kato
March 1988,
Revista espanola de fisiologia,
S Nagamitsu, and
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H Kato
January 1985,
Archivos de neurobiologia,
S Nagamitsu, and
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Y Yamashita, and
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H Kato
January 1985,
Peptides,
S Nagamitsu, and
T Matsuishi, and
T Kisa, and
H Komori, and
M Miyazaki, and
T Hashimoto, and
Y Yamashita, and
E Ohtaki, and
H Kato
January 1993,
European journal of cancer (Oxford, England : 1990),
