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The effect of pregnancy and lactation on GABA(A) receptor and central- and peripheral-type benzodiazepine receptors (CBR and PBR, respectively) was studied in female Sprague-Dawley rats. Pregnancy was associated with increased CBR density (on day 19) in the hippocampus and with decreased [3H]Ro 15-1788-specific binding in the hypothalamus during pregnancy and lactation. A similar decrease in [3H]PK 11195-specific binding was observed in the hypothalamus and pituitary. An increase in PBR density in the ovary and uterus was observed during pregnancy, while adrenal PBR density was down-regulated during pregnancy and lactation. It seems that the hormonal changes occurring during pregnancy and lactation play a role in the regulation of CBR and PBR in discrete tissues.
R Weizman, and
E Dagan, and
S H Snyder, and
M Gavish
April 1989,
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R Weizman, and
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M Gavish
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R Weizman, and
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R Weizman, and
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October 2004,
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February 2006,
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R Weizman, and
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M Gavish
July 1986,
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R Weizman, and
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May 1982,
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R Weizman, and
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M Gavish
January 1993,
Life sciences,
R Weizman, and
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M Gavish
September 1997,
General pharmacology,
R Weizman, and
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January 1989,
Annual review of pharmacology and toxicology,
