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Many T cells with auto-aggressive potential are deleted in the thymus. Although some of these escape to the general circulation, they do not usually damage organs such as the pancreas. To investigate the mechanisms preventing autoimmunity, we generated transgenic mice expressing known genes under the control of various promoters. We found that the occurrence of autoaggression depended on factors such as the precursor frequency of responding T cells, their state of activation, their accessibility to the autoantigen, the physicochemical properties of the autoantigen, the possibility of priming by environmental antigens which mimic the target antigen, and some inflammatory reaction in the target site.
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
November 2004,
Autoimmunity reviews,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
February 2003,
Der Internist,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
January 2000,
Reviews in immunogenetics,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
February 1997,
Human immunology,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
December 1990,
Immunological reviews,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
December 1994,
Current opinion in immunology,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
January 1986,
Current topics in microbiology and immunology,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
January 2011,
Bulletin of mathematical biology,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
April 2005,
Immunological reviews,
J F Miller, and
W R Heath, and
J Allison, and
G Morahan, and
M Hoffmann, and
C Kurts, and
H Kosaka
August 2002,
International immunology,
