BIOMAT Database Logo BIOMAT Database Logo

Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. 1997

K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Department of Pediatrics, University of Alabama at Birmingham School of Medicine, USA.

OBJECTIVE To determine the prevalence and temporal changes of sensorineural hearing loss (SNHL) among children with clinically inapparent (asymptomatic) congenital cytomegalovirus (CMV) infection identified from a cohort of newborn infants screened for congenital CMV infection. METHODS The study population consisted of 307 children with documented asymptomatic congenital CMV infection, 76 uninfected siblings of children with asymptomatic congenital CMV infection, and 201 children whose neonatal screen for congenital CMV infection showed negative results. Audiologic evaluations were completed for all children to determine their hearing status. RESULTS SNHL occurred only in children with congenital CMV infection. Of the children with asymptomatic congenital CMV infection, 22 (7.2%; 95% confidence interval, 4.5% to 10.6%) had SNHL. Among the children with hearing loss, further deterioration of hearing occurred in 50.0%, with the median age at first progression at 18 months (range, 2 to 70 months). Delayed-onset SNHL was observed in 18.2% of the children, with the median age of detection at 27 months (range, 25 to 62 months). Fluctuating SNHL was documented in 22.7% of the children with hearing loss. CONCLUSIONS Asymptomatic congenital CMV infection is likely a leading cause of SNHL in young children. The continued deterioration of hearing and delayed onset of SNHL in these children emphasizes the need for continued monitoring of their hearing status.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003586 Cytomegalovirus Infections Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults. CMV Inclusion,CMV Inclusions,Congenital CMV Infection,Congenital Cytomegalovirus Infection,Cytomegalic Inclusion Disease,Cytomegalovirus Colitis,Cytomegalovirus Inclusion,Cytomegalovirus Inclusion Disease,Cytomegalovirus Inclusions,Inclusion Disease,Perinatal CMV Infection,Perinatal Cytomegalovirus Infection,Renal Tubular Cytomegalovirus Inclusion,Renal Tubular Cytomegalovirus Inclusions,Salivary Gland Virus Disease,Severe Cytomegalovirus Infection,Severe Cytomegalovirus Infections,Infections, Cytomegalovirus,CMV Infection, Congenital,CMV Infection, Perinatal,Colitis, Cytomegalovirus,Congenital CMV Infections,Congenital Cytomegalovirus Infections,Cytomegalic Inclusion Diseases,Cytomegalovirus Colitides,Cytomegalovirus Inclusion Diseases,Cytomegalovirus Infection,Cytomegalovirus Infection, Congenital,Cytomegalovirus Infection, Perinatal,Cytomegalovirus Infection, Severe,Cytomegalovirus Infections, Severe,Disease, Cytomegalic Inclusion,Disease, Cytomegalovirus Inclusion,Diseases, Cytomegalovirus Inclusion,Inclusion Disease, Cytomegalic,Inclusion Disease, Cytomegalovirus,Inclusion Diseases,Inclusion Diseases, Cytomegalovirus,Inclusion, CMV,Inclusion, Cytomegalovirus,Infection, Congenital CMV,Infection, Congenital Cytomegalovirus,Infection, Cytomegalovirus,Infection, Perinatal CMV,Infection, Perinatal Cytomegalovirus,Infection, Severe Cytomegalovirus,Perinatal CMV Infections,Perinatal Cytomegalovirus Infections
D005260 Female Females
D006319 Hearing Loss, Sensorineural Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM. Deafness Neurosensory,Deafness, Neurosensory,Deafness, Sensoryneural,Neurosensory Deafness,Sensorineural Hearing Loss,Sensoryneural Deafness,Cochlear Hearing Loss,Hearing Loss, Cochlear,Deafnesses, Neurosensory,Deafnesses, Sensoryneural,Neurosensory Deafnesses,Sensoryneural Deafness,Sensoryneural Deafnesses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001299 Audiometry The testing of the acuity of the sense of hearing to determine the thresholds of the lowest intensity levels at which an individual can hear a set of tones. The frequencies between 125 and 8000 Hz are used to test air conduction thresholds and the frequencies between 250 and 4000 Hz are used to test bone conduction thresholds. Audiometries
D017668 Age of Onset The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual. Age-at-Onset,Age at Onset,Onset Age

Related Publications

K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection.
December 1992, Pediatrics,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Hearing Loss in Children With Asymptomatic Congenital Cytomegalovirus Infection.
March 2017, Pediatrics,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Fluctuating and/or progressive sensorineural hearing loss in children.
August 1994, The Laryngoscope,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Sensorineural Hearing Loss and Congenital Cytomegalovirus Infection.
March 2018, Journal of pediatric genetics,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Congenital cytomegalovirus infection and sensorineural hearing loss.
January 1984, Ear and hearing,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Progressive hearing loss in children with congenital cytomegalovirus.
April 1991, Journal of paediatrics and child health,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Congenital Human Cytomegalovirus Infection Inducing Sensorineural Hearing Loss.
January 2021, Frontiers in microbiology,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Fluctuating sensorineural hearing loss in children.
August 2002, Otolaryngologic clinics of North America,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Progressive sensorineural hearing loss in children with congenital diaphragmatic hernias.
February 2009, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale,
K B Fowler, and F P McCollister, and A J Dahle, and S Boppana, and W J Britt, and R F Pass
Congenital cytomegalovirus infection: a cause of sensorineural hearing loss.
December 1987, Archives of disease in childhood,
Copied contents to your clipboard!