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The effect of triterpen glycosides of cauloside C from Caulophyllum robustum, theasaponine from Thea sinensis ahd stichoposide A from Stichopus japonicus on multiplication and biosynthesis of RNA in the cells of a 7-hour culture of Saccharomyces carlsbergensis was studied. It was shown that cauloside C, theasaponine and stichoposide A in concentrations of 7.5 gamma/ml inhibited multiplication of the yeast cells by 65, 10 and 90 per cent respectively. The summation RNA of the yeast cells is divided into 3 zones on Sephadex G-100. The glycosides induced no pronounced changes in the chromotographic profile of RNA. Biosynthesis of the transport and ribosomal RNA were inhibited to the same extent. Triterpen glycosides inhibited the biosynthesis of RNA at the stage of 14C-uridine in corporation into the nucleotide pool of the yeast cells.
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
January 1978,
Prikladnaia biokhimiia i mikrobiologiia,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
January 1978,
Antibiotiki,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
January 1979,
Antibiotiki,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
February 1968,
The Journal of biological chemistry,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
February 2014,
G3 (Bethesda, Md.),
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
December 1967,
European journal of biochemistry,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
January 1981,
Mikrobiologiia,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
January 1987,
Acta microbiologica Bulgarica,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
March 1971,
Archives of biochemistry and biophysics,
M M Anisimov, and
S I Baranova, and
L I Strigina, and
N S Chetyrina, and
I N Sokol'skiĭ
March 1979,
The Biochemical journal,
