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The influence of indobufen (200 mg twice daily for 10 days) on platelet lipid peroxidation and phospholipid metabolism in diabetic patients was investigated. We have studied 18 patients with type I of diabetes mellitus. The duration of disease varied between 3 and 25 years (average 11 years). All patients showed symptoms of diabetic angiopathy. Investigations were carried out after restoring the carbohydrate balance. The following tests were performed before and after a 10 day treatment with indobufen: malondialdehyde, conjugated dienes and lipid hydroperoxides, phospholipids, fatty acids. We observed a significantly higher production of lipid peroxidation products in diabetic platelets compared to control platelets. After a 10 day treatment with indobufen the intensity of peroxidation lowered significantly. The phospholipid composition of diabetic platelets showed a significant increase in lysophosphoglycerides fraction compared to the control platelets. After the indobufen treatment a significant decrease in sphingomyelin content was observed. In other phospholipid fractions no significant differences were observed.
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
September 1995,
Thrombosis research,
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
May 1985,
Thrombosis research,
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
March 1983,
British medical journal (Clinical research ed.),
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
January 1983,
British medical journal (Clinical research ed.),
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
April 1978,
Clinical biochemistry,
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
January 1991,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
August 1976,
Biochimica et biophysica acta,
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
September 1992,
Prostaglandins, leukotrienes, and essential fatty acids,
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
June 1991,
Biochimica et biophysica acta,
A Dmoszyńska, and
B Sokołowska, and
A Walter-Croneck, and
K Przesmycki, and
A Ledwozyw
June 1986,
Journal of neurochemistry,
