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Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [14C]ethanol in body water plus hepatic metabolism could account for [14C]ethanol absorbed from the pylorus-ligated stomach. Intact [14C]ethanol in systemic body water accounted for 84 +/- 1.9% of the [14C]ethanol absorbed from the stomach over a 30-min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [14C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [14C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.
M D Levitt, and
J Furne, and
E DeMaster
December 1993,
Alcoholism, clinical and experimental research,
M D Levitt, and
J Furne, and
E DeMaster
January 1994,
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement,
M D Levitt, and
J Furne, and
E DeMaster
June 1992,
Digestive diseases and sciences,
M D Levitt, and
J Furne, and
E DeMaster
July 2000,
Alcoholism, clinical and experimental research,
M D Levitt, and
J Furne, and
E DeMaster
November 1998,
Gut,
M D Levitt, and
J Furne, and
E DeMaster
May 1997,
Hepatology (Baltimore, Md.),
M D Levitt, and
J Furne, and
E DeMaster
October 1996,
Gastroenterology,
M D Levitt, and
J Furne, and
E DeMaster
December 1996,
Alcoholism, clinical and experimental research,
M D Levitt, and
J Furne, and
E DeMaster
November 1989,
Gastroenterology,
M D Levitt, and
J Furne, and
E DeMaster
May 1995,
The journals of gerontology. Series A, Biological sciences and medical sciences,
