-transparent.png){kind=logo}
We investigate the effect of EGF on IP3 production, PLC gamma phosphorylation, calcium transients in rat hepatocytes isolated in quiescent liver (G0 phase of cell cycle) and at 4 h (G1 phase of cell cycle) and 24 h (M phase of cell cycle) after partial hepatectomy. Our results show that EGF does not utilize IP3 and calcium as its signal transduction molecules when the hepatocytes are in vivo stimulated to entry in the cell cycle. In particular the growth factor does not phosphorylate PLC gamma and induces a decrease in IP3 content. These data suggest that EGF utilizes different signal transduction to send information from receptor to nucleus during PH with respect to the quiescent liver.
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
March 2002,
European journal of pharmacology,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
November 2005,
European journal of pharmacology,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
December 2010,
Development genes and evolution,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
March 1975,
Die Naturwissenschaften,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
December 2022,
Journal of visualized experiments : JoVE,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
February 2018,
Journal of visualized experiments : JoVE,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
June 2014,
Genetics and molecular biology,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
August 1982,
Cancer research,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
December 1985,
Experimental cell research,
M Marino, and
S Spagnuolo, and
M Cavallini, and
F Terenzi, and
M T Mangiantini, and
S Leoni
November 2012,
Histochemistry and cell biology,
