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Atrial natriuretic peptide (ANP) is released excessively in spontaneously hypertensive rats (SHR), and vasodepression is its main effect on the blood vessels. The aim of the study was to investigate the changes in ANP secretion in the cerebral vasospasm following subarachnoid hemorrhage (SAH) in SHRs. The SAH was induced by the injection of 100 microliters of unheparinized, autologous blood into the cerebrospinal fluid (CSF), via a canule formerly inserted into the cisterna magna (CM). In the sham SAH group the SAH was imitated with 0.9% saline injection. The concentrations of ANP in the blood samples obtained in the acute and chronic stages of vasospasm were radioimmunoassayed with commercial RIA kits (Peninsula RIK 9103). It was found that both SAH and sham SAH induced a significant increase in plasma ANP in the chronic phase of vasospasm. No such changes were observed in the acute phase. This shows that the chronic cerebral vasospasm following SAH considerably enhances the ANP secretion in SHRs, probably through the increased endothelin release. These compensatory and regulatory mechanisms help prevent the development of brain oedema and the progression of vasopasm through secondary vasodilation.
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
October 1990,
The American journal of physiology,
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
February 1996,
Hypertension (Dallas, Tex. : 1979),
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
November 1992,
American journal of hypertension,
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
July 1988,
American journal of hypertension,
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
December 1991,
Journal of hypertension,
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
April 1990,
The American journal of physiology,
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
June 1994,
Hypertension (Dallas, Tex. : 1979),
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
June 1989,
Hypertension (Dallas, Tex. : 1979),
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
September 1992,
Cardiovascular research,
J Jośko, and
S Hendryk, and
H Jedrzejowska-Szypułka, and
B Gwóźdź, and
Z S Herman, and
D Latka, and
N Kopeć
September 1992,
Hypertension (Dallas, Tex. : 1979),
