-transparent.png){kind=logo}
Mechanisms of the inhibitory effect of vitamin E on the process of lipid peroxidation (LPO) in biological membranes are studied. Both alpha-tocopherol and its derivatives (a-tocopherylacetate, o- and p-tocopherylquinones possess no radical scavenging activity) inhibit non-enzymatic (Fe2+ + ascorbate)-induced LPO and prevent LPO-dependent inhibition of Ca2+ transport in sarcoplasmic reticulum membranes from skeletal muscles. The protective effect of alpha-tocopherylacetate, tocopherilquinones and partially of alpha-tocopherol is due to a stabilizing effect of these compounds on sarcoplasmic reticulum membranes, registered by a decrease of fluidity of membrane lipid bilayer (probed by nitroxile radical TEMPO) and by a decrease of its passive permeability for Ca2+. Under the enzymatic NADPH-dependent LPO induction in rat liver microsomal fraction a strong inhibitory effect of tocopherylquinones is similar to the effect of other electron acceptors (methylnaphtoquinone, TEMPO) and is due to their ability to compete with LPO reaction for reducing equivalents in NADPH-dependent electron carriers wich results in the formation of hydroxy-derivatives having pronounced radical scavenging activity.
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
January 1988,
Progress in clinical and biological research,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
September 1987,
Biulleten' eksperimental'noi biologii i meditsiny,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
January 1987,
Farmakologiia i toksikologiia,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
December 1979,
Radiation research,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
January 1978,
Voprosy meditsinskoi khimii,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
January 1988,
Life sciences,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
October 1994,
Bioorganicheskaia khimiia,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
June 1976,
Biochimica et biophysica acta,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
February 1996,
Archives of biochemistry and biophysics,
Iu V Arkhipenko, and
S K Dobrina, and
V E Kagan, and
Iu P Kozlov, and
N K Nadirov, and
V A Pisarev, and
V B Ritov, and
R Kh Khafizov
November 1992,
Equine veterinary journal,
