Biomaterial Database

Discharge patterns of the nucleus parabrachialis lateralis neurons of the cat during sleep and waking. 1977

H Saito, and K Sakai, and M Jouvet

Discharge patterns of the nucleus parabrachialis lateralis (PbL) neurons located in the dorsolateral pontine tegmentum were investigated in 7 unrestrained, freely behaving cats with a multiwire electrode bundle method. Among 84 PbL units recorded so far, 31% of the units exhibited a marked reduction or complete cessation of firing during paradoxical sleep (PS) (PS-off cells), while 55% of the units exhibited an increase of firing during PS (PS-on cells) as compared with quiet wakefulness (QW) and slow wave sleep (SWS). The remaining 14% of the PbL units exhibited no remarkable change of firing rate and pattern during the sleep-walking cycle. The PbL PS-off cells were further characterized by a slow and regular firing pattern during QW and SWS, and they were similar in several respects to the PS-off cells reported in the nucleus raphe dorsalis and locus coeruleus complex. Six of the PbL PS-on cells were tightly phase-locked with PGO waves, and the spikes preceded by 5-25 msec the onset of the PGO waves recorded in the lateral geniculate nucleus. Seven other PbL PS-on cells were related to the locomotor activity observed in active wakefulness. In light of the present results, the functional significance of the PbL units has been discussed.

UI	MeSH Term	Description	Entries
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D011149	Pons	The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM.	Pons Varolii,Ponte,Pons Varolius,Pontes,Varolii, Pons,Varolius, Pons
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012890	Sleep	A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.	Sleep Habits,Sleeping Habit,Sleeping Habits,Habit, Sleep,Habit, Sleeping,Habits, Sleep,Habits, Sleeping,Sleep Habit
D014851	Wakefulness	A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.	Wakefulnesses