-transparent.png){kind=logo}
OBJECTIVE We assessed cord blood for levels of interleukin-4 (IL-4), interleukin-10 (IL-10), and p55 (sTNFR-I) and p75 (sTNFR-II) soluble tumor necrosis factor receptors. METHODS Umbilical cord IL-4, IL-10, tumor necrosis factor alpha (TNF alpha), sTNFR-I, and sTNFR-II were measured in 21 normal appropriately grown newborns delivered vaginally (normal pregnancy), and 3 abnormal pregnancies (1 preterm delivery, 1 premature rupture of membranes with chorioamnionitis, and 1 abruptio placentae with fetal and neonatal distress). Umbilical cord arterial blood pH and PO2 were also measured. RESULTS The TNF alpha, sTNFR-I, and sTNFR-II were detectable in all cord blood samples in normal pregnancies. IL-4 was detected in 10 of 21 samples (47.6%), and IL-10 was undetectable in normal pregnancies. IL-10 could be detected in the cases with chorioamnionitis and abruptio placentae. Soluble tumor necrosis factor receptors in the case with preterm delivery and the case with abruptio placentae were elevated compared with the levels in control samples. CONCLUSIONS Both the p55 and p75 soluble tumor necrosis factor receptors are physiologic constituents of term cord blood. An immunosuppressive role of IL-10 and a protective role of soluble tumor necrosis factor receptors are suggested in abnormal pregnancies. However, in view of the small number of abnormal pregnancies, these observations must be considered preliminary.
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
June 1996,
The Journal of infectious diseases,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
March 1995,
The Journal of rheumatology,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
August 1993,
Arthritis and rheumatism,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
August 1997,
Critical care medicine,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
December 1993,
Biochemical and biophysical research communications,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
September 1996,
Obstetrics and gynecology,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
January 2000,
Methods in molecular medicine,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
December 1996,
Journal of neuroimmunology,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
January 1996,
Anesthesiology,
T Hata, and
T Kawamura, and
R Fujiwaki, and
S Aoki, and
K Hata, and
K Inada
February 1994,
Acta paediatrica Japonica : Overseas edition,
