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Edema is a typical sign in kwashiorkor, which is present in a subset of patients with protein-energy-malnutrition (PEM). The pathophysiology of this edema is not well established. One of the abnormalities found in kwashiorkor is reduced concentrations of antioxidants, suggesting a compromised capacity to neutralize free radicals, which are known to induce tissue damage. We have studied plasma concentrations of several mediators of the inflammatory cascade. Concentrations of interleukin 6 (IL-6), C-reactive protein, and the soluble receptors of tumor necrosis factor alpha (sTNFR-p55 and sTNFR-p75) are greater in children with PEM, particularly in those with kwashiorkor, whereas soluble receptors of IL-6 (sIL6R-gp80) and IL-1 receptor antagonist concentrations are not significantly different from those of healthy children. In addition, concentrations of IL-6, sTNFR-p55, and sTNFR-p75 are greater in kwashiorkor patients irrespective of the presence of infection. Antioxidant status, as determined by plasma concentrations of glutathione and vitamin E, is significantly reduced in kwashiorkor patients. These data support the notion that children with edematous malnutrition show increased inflammatory reactivity that may contribute to edema formation.
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
December 2002,
Mediators of inflammation,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
January 1980,
Indian journal of pediatrics,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
June 1983,
Annals of tropical paediatrics,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
March 1990,
European journal of clinical nutrition,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
December 1992,
The West Indian medical journal,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
January 1983,
Journal of pediatric gastroenterology and nutrition,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
September 1992,
The Pediatric infectious disease journal,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
October 1981,
Hospital formulary,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
February 1998,
Journal of tropical pediatrics,
R W Sauerwein, and
J A Mulder, and
L Mulder, and
B Lowe, and
N Peshu, and
P N Demacker, and
J W van der Meer, and
K Marsh
December 1984,
Tropical and geographical medicine,
