Stochastic versions of the Hodgkin-Huxley equations. 1997

R F Fox
School of Physics, Georgia Institute of Technology, Atlanta 30332-0430, USA. ron.fox@physics.gatech.edu

A Hodgkin-Huxley model algorithm for the numerical simulation of noise in neurons is contracted from a master equation description (cellular automoton) into a Langevin description. This reduction reduces the time required for a simulation by about two orders of magnitude. Earlier work is summarized, condensed, and made explicit to make the algorithm transparent and facilitate applications. Two approximate treatments are reported. An extension of this approach is presented that includes spatial dependence and the propagation of a noisy action potential along an axon.

UI MeSH Term Description Entries
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D001369 Axons Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body. Axon
D001703 Biophysics The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things. Mechanobiology
D013269 Stochastic Processes Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables. Process, Stochastic,Stochastic Process,Processes, Stochastic
D055592 Biophysical Phenomena The physical characteristics and processes of biological systems. Biophysical Concepts,Biophysical Processes,Biophysical Phenomenon,Biophysical Process,Biophysical Concept,Concept, Biophysical,Concepts, Biophysical,Phenomena, Biophysical,Phenomenon, Biophysical,Process, Biophysical,Processes, Biophysical

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