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Azlocillin, in vitro four to eight times more effective against Pseudomonas aeruginosa than carbenicillin, was administered to 30 patients severely ill and having an additional pseudomonas infection. The drug was given at a dose of 4-6 g, in one case 8 g, per day, sometimes together with an aminoglycoside. Treatment was effective in 20, improvement occurred in five and failure only in four. In one instance the effect of the drug could not be evaluated. Results were particularly striking in septicaemia and necrotising external otitis. Pulmonary and wound infections in patients with circulatory disturbances did not respond so well. There were no serious side effects. The drug should not as yet be used at too high a dosage.
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
May 1982,
Medicina clinica,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
May 1982,
The Journal of antimicrobial chemotherapy,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
January 1979,
Arzneimittel-Forschung,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
February 1979,
Klinische Monatsblatter fur Augenheilkunde,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
February 1982,
Casopis lekaru ceskych,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
December 1977,
Archiv fur orthopadische und Unfall-Chirurgie,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
January 1979,
Arzneimittel-Forschung,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
May 1983,
The Journal of antimicrobial chemotherapy,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
January 1977,
Infection,
E B Helm, and
W Ristow, and
P M Shah, and
P Schacht, and
W Stille
January 1976,
Infection,
