-transparent.png){kind=logo}
Purified bovine neurosecretory granules and their corresponding membranes were prepared after fractionation and purification processes from bovine pituitaries. An adenylate cyclase activity was detected both in the granules (apparent Km = 0.5 mM) and the corresponding preparations of the membranes (apparent Km = 0.5 mM). This enzyme was activated by fluoride in a way markedly dependent on the concentration of this ion, and with a maximum for a concentration of F- = 3.5 mM. The cyclase activity was also significantly enhanced by GTP. The reaction rate showed a strong dependence on the molar ration [Mg2+]/[ATP] with maximal velocity for 7. It is suggested that this activity might play an important role in the control and regulation of neurosecretion in the neurohypophysis.
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
December 1977,
Biochemical and biophysical research communications,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
January 1986,
Journal of cyclic nucleotide and protein phosphorylation research,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
February 1981,
Science (New York, N.Y.),
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
February 1975,
The Journal of biological chemistry,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
April 1976,
The Journal of biological chemistry,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
September 1986,
Analytical biochemistry,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
December 1972,
Biochimica et biophysica acta,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
February 1974,
Endocrinology,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
January 1980,
Annals of the New York Academy of Sciences,
D Bonne, and
P Nicolas, and
M Lauber, and
M Camier, and
A Tixier-vidal, and
P Cohen
August 1978,
The Journal of biological chemistry,
