-transparent.png){kind=logo}
The pattern of injury of the specific cell structures of the central nervous system (CNS) is different in the various types of the dementia syndrome. We challenged the hypothesis that this could be reflected in specific patterns of brain-specific proteins in the cerebrospinal fluid (CSF). The neuron-specific enolase (NSE), S-100, myelin basic protein (MBP) and lactate levels were retrospectively analyzed in the CSF of 159 patients with various types of dementia. A previous study from our department demonstrated age-related reference values for the brain-specific proteins in the CSF. The present study affirmed the strikingly high NSE and S-100 values in the CSF of patients with autopsydiagnosed Creutzfeld-Jacob disease: NSE, S-100 and MBP levels in the CSF of patients with various other types of dementia, and controls, did not differ significantly. Therefore we concluded that a single determination of CSF concentrations of these brain-specific proteins were of little value in the differential diagnosis of the dementia syndrome. In the diagnosis of normal pressure hydrocephalus increased levels of CSF lactate may be helpful.
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
September 1995,
Acta neurologica Scandinavica,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
June 1992,
Clinical chemistry,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
November 1989,
Journal of neurosurgery,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
August 2003,
Brain research bulletin,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
June 1988,
Disease markers,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
November 2001,
Journal of neurology, neurosurgery, and psychiatry,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
January 1985,
Virchows Archiv. A, Pathological anatomy and histopathology,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
January 2001,
Journal of the neurological sciences,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
January 1989,
Acta neurologica Belgica,
P T Nooijen, and
H C Schoonderwaldt, and
R A Wevers, and
O R Hommes, and
K J Lamers
January 2006,
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
