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We evaluated 85 human immunodeficiency virus (HIV)-negative patients with tuberculosis for clinical features and CD4 cell counts. Thirty-seven patients had low CD4 cell counts (mean +/- SD, 341 +/- 116 cells/microL), and 48 patients had normal CD4 cell counts (mean +/- SD, 830 +/- 254 cells/microL). CD4 cell counts were most strongly correlated with total lymphocyte counts (r = 0.84). If total lymphocyte count was excluded, depressed CD4 cell counts were significantly associated with low serum albumin levels, extensive pulmonary disease, low body-mass index, and low hematocrit. Of these four variables, multivariate linear discriminant analysis revealed that the serum albumin level was the best single predictor of low CD4 cell counts and that the other three variables did not improve predictive value. Because these four variables are markers of severe tuberculosis, these findings suggest that disease severity is associated with greater depression of the total lymphocyte and CD4 cell counts. The CD4 cell counts returned to normal levels in most patients after 1 month of therapy.
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
January 2006,
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
November 1993,
The American review of respiratory disease,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
November 1999,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
July 2002,
The Journal of infectious diseases,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
January 1994,
American journal of epidemiology,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
December 1995,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
October 1995,
Archives of family medicine,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
February 1998,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
October 1994,
The Journal of infectious diseases,
B E Jones, and
M M Oo, and
E K Taikwel, and
D Qian, and
A Kumar, and
E R Maslow, and
P F Barnes
March 2002,
The Journal of infectious diseases,
