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OBJECTIVE Many studies have suggested that glycogen in donor livers is an important fuel during cold ischemic time and at reperfusion. However, it remains unclear as to whether the depression of glycogen content in the graft results in a critical derangement of energy metabolism after reperfusion. The purpose of this study was to assess the possible implications of the glycogen concentration of donor livers for the hepatic energy metabolism after reperfusion. METHODS The glycogen content of 28 donor livers and the plasma concentrations of metabolic substrates were measured during liver transplantation. RESULTS Gluconeogenesis was maintained even in the glycogen-depleted graft at reperfusion. However, glycogen-depleted grafts produced more ketone bodies until 24 h after reperfusion. Free carnitine concentrations in these patients were significantly higher than those in the patients with glycogen-nondepleated grafts until 48 h after reperfusion. CONCLUSIONS A glycogen-depleted liver graft may restore essential metabolic function by producing energy substrates through enhanced ketogenesis in the postreperfusion period. The enhanced production of carnitine by the graft provides a substrate for the production of ketone bodies and thus may be relevant to the enhanced ketogenesis.
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
March 2007,
American journal of physiology. Endocrinology and metabolism,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
January 1971,
Experientia,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
January 2002,
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
February 1993,
Transplantation proceedings,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
August 1977,
Fortschritte der Medizin,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
February 1959,
Bollettino della Societa italiana di biologia sperimentale,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
January 1984,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
December 1963,
Bollettino della Societa italiana di biologia sperimentale,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
November 1978,
Poultry science,
C Miki, and
K Iriyama, and
J D Harrison, and
B K Gunson, and
M D'Silva, and
H Suzuki, and
P McMaster
April 1954,
Pracovni lekarstvi,
